Effect of alcoholic and aqueous extracts of Punica granatum on normal and cancerous cell lines
Keywords:
alcoholic extracts, aqueous extracts, punica granatum, HdFn and MCF-7 cell lineAbstract
Pomegranate, or Punica granatum, belongs to the monogeneric family Punicaceae and is primarily found in Iran, which is thought to be its primary place of origin. The pharmacological and toxicological effects of Pg and its chemical constituents include antioxidant, anti-inflammatory (through blocking pro-inflammatory cytokines), anti-cancer, and anti-angiogenesis activity. One of the top five global causes of adult mortality is cancer, and its toll is unreasonably increasing. The Global Cancer Observatory's data show. In this study two Punica grantum extracts-alcoholic and aqueous-were used in this study. The two extracts' capacity to prevent the growth of cancer cells and determine the optimal dose for each cell line. As the concentration of the two extracts increases, the results demonstrate a linear decrease in optical density and an increase in cellular growth inhibition. This study's findings highlight the potential anti-cancer properties of Punica grantum extracts, particularly the Punica grantum extract. When compared to currently available cytotoxic medicines, these extracts demonstrated a significant cytotoxic effect against breast cells while demonstrating non-cytotoxic effects on normal human cells. The findings of this study call for more research, notably on the extracts' cytotoxic mechanisms, which can also be used to create new cancer treatments.
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