Effect of quorum sensing tyrosol (antibiofilm and antibacteria) in Streptococcus mutans: narrative review


  • Indah Listiana Kriswandini Department of Oral Biology, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia
  • Ira Arundina Department of Oral Biology, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia
  • Devy Ratriana Amiati Post-Graduate Program in Dentistry, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia


biofilm, streptococcus mutans, tyrosol, Quorum Sensing


Background: Streptococcus mutans is a gram-positive bacteria in the form of a cocci, which is a normal flora of the oral cavity. Streptococcus mutans forms a biofilm layer consisting of a matrix of Extracellular Polymeric Substances. Biofilm can be a health problem, one of which is dental caries. Tyrosol is Quorum Sensing which is owned by Candida albicans and has anti-biofilm and antibacterial properties on Streptococcus mutans.

Purpose: To analyze the effect of quorum sensing tyrosol (antibiofilm and antibacterial) on Streptococcus mutans.

Method: This study uses the narrative review method. The literature sources used come from the digital databases ScienceDirect, Pubmed, and Proquest. Inclusion criteria published in the period 2005-2022, in the form of research results or review articles, and can be accessed in full text.

Discussion: Some literature states that tyrosol can cause a decrease in Streptococcus mutans biofilm formation. Tyrosol synthesizes the Flo8 gene which plays a role in hypha formation and virulence. Flo8 can induce ALS1 to inhibit AgI/II synthesis. The phenolic content in tyrosol can suppress the production of glucosyltransferases produced by S. mutans, causing a decrease in biofilm formation, damage the cytoplasmic membrane and inhibit bacterial DNA synthesis.

Conclusion: Tyrosol can inhibit biofilm formation and antibacterial S. mutans by involving the QS mechanism. The phenolic content in tyrosol has anti-biofilm and antibacterial properties on S. mutans.


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How to Cite

I. Listiana Kriswandini, I. Arundina, and D. Ratriana Amiati, “Effect of quorum sensing tyrosol (antibiofilm and antibacteria) in Streptococcus mutans: narrative review”, J. A. Med. Sci, vol. 3, no. 4, pp. 01–04, Oct. 2023.