Journal of Advance Medical Sciences 2023-11-30T16:08:41+00:00 Dzarc Publications [email protected] Open Journal Systems <p><strong>Journal of Advance Medical Sciences</strong> is a peer-reviewed, refereed, and open access journal that focuses on critical and creative research and provides an open access research journal platform for scholars and researchers to exchange their research work results among professionals throughout the world. This journal publishes research articles in all fields of Medical science but is not limited to.</p> Effect of quorum sensing tyrosol (antibiofilm and antibacteria) in Streptococcus mutans: narrative review 2023-11-14T11:37:14+00:00 Indah Listiana Kriswandini [email protected] Ira Arundina [email protected] Devy Ratriana Amiati [email protected] <p><strong>Background: </strong><em>Streptococcus mutans</em> is a gram-positive bacteria in the form of a cocci, which is a normal flora of the oral cavity. <em>Streptococcus mutans</em> forms a biofilm layer consisting of a matrix of Extracellular Polymeric Substances. Biofilm can be a health problem, one of which is dental caries. Tyrosol is <em>Quorum Sensing</em> which is owned by <em>Candida albicans</em> and has anti-biofilm and antibacterial properties on <em>Streptococcus mutans</em><em>.</em></p> <p><strong>Purpose: </strong>To analyze the effect of <em>quorum sensing</em> tyrosol (antibiofilm and antibacterial) on <em>Streptococcus mutans</em><em>.</em></p> <p><strong>Method:</strong> This study uses the narrative review method. The literature sources used come from the digital databases ScienceDirect, Pubmed, and Proquest. Inclusion criteria published in the period 2005-2022, in the form of research results or review articles, and can be accessed in full text.</p> <p><strong>Discussion: </strong>Some literature states that tyrosol can cause a decrease in <em>Streptococcus mutans</em> biofilm formation. Tyrosol synthesizes the <em>Flo8</em> gene which plays a role in hypha formation and virulence. <em>Flo8</em> can induce ALS1 to inhibit AgI/II synthesis. The phenolic content in tyrosol can suppress the production of <em>glucosyltransferases</em> produced by <em>S. mutans</em>, causing a decrease in biofilm formation, damage the cytoplasmic membrane and inhibit bacterial DNA synthesis.</p> <p><strong>Conclusion: </strong>Tyrosol can inhibit biofilm formation and antibacterial <em>S. mutans</em> by involving the <em>QS</em> mechanism. The phenolic content in tyrosol has anti-biofilm and antibacterial properties on <em>S. mutans</em><em>.</em></p> 2023-10-04T00:00:00+00:00 Copyright (c) 2023 Indah Listiana Kriswandini , Ira Arundina, Devy Ratriana Amiati