M1/M2 macrophage polarity in elderly patients with periodontitis and diabetes mellitus
Keywords:
periodontitis, diabetes mellitus, age, M1/M2 macrophage polarityAbstract
Background: Periodontitis is a common chronic infectious disease related to diabetes mellitus. The progression of periodontal damage under diabetic condition caused the imbalance of immune defense and inflammation where macrophage plays a role. Age also affects dysregulated macrophage function. Macrophage has the ability to change into an M1 or M2 phenotype.
Aim: This literature aimed to understand M1/M2 polarity in an elderly patient with periodontitis and diabetes mellitus.
Discussion: Periodontitis exacerbated by diabetes mellitus in elderly patients enhanced M1 phenotype macrophage via activation of TLR and overproduction of ROS, and suppressed M2 phenotype by fewer IL-4 receptors available for ligand binding in the elderly.
Conclusion: Enhanced M1 and suppressed M2 polarity in the elderly patient with periodontitis and diabetes mellitus might take responsibility for aggravated periodontal damage.
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Copyright (c) 2022 Cindy Ramadhan Putri, Retno Pudji Rahayu, Rini Devijanti Ridwan
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