Advances in microbial bioreactors: enhancing yield through process intensification
Keywords:
Microbial Bioreactors, Process Intensification (PI), SEST paradigm, IraqAbstract
Developments in Microbial Bioreactors: Increasing Yield by Intensifying the Process Critical issues in microbial bioreactors, such as low productivity, ineffective substrate conversion, and excessive resource consumption, can be resolved via Process Intensification (PI). Using the SEST paradigm (Structure, Energy, Synergy, Time), this research examines current PI techniques in microbial bioprocessing and assesses their effects on sustainability and yield enhancement. Three key technologies show particular promise: perfusion-based cell cultures (achieving cell densities 3-10 times higher than batch processing), continuous-flow biocatalysis (improving volumetric productivity 3-5 fold), and microbubble-assisted mass transfer (increasing oxygen transfer efficiency by 40-60% while reducing energy requirements). Improved process control, decreased environmental impact, and increased volumetric output are just a few of the measurable advantages that these methods offer. A route towards adaptable, responsive biomanufacturing systems is made possible by the combination of PI with metabolic engineering and digital monitoring technologies. Implementing PI provides a convincing approach to creating high-performance, sustainable microbial bioreactors for next-generation industrial biotechnology, notwithstanding technological and regulatory obstacles.
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