Study association between vitamin d3 with liver function and kidney in student

Authors

  • Israa Ali Hussein Department of Chemistry, College of Science, Karbala University, Karbala, Iraq

Keywords:

vitamin d3, kidney, liver and other functions

Abstract

This investigation examined how much vitamin D3 students in the Education of Education have in relation to their liver and kidney health. In 2023, 90 samples (20–30 years old, 52 men, and 38 women) were gathered.1.12 - 2018.2.12. The measurement of (Vitamin D3, Urea, Uric acid, Creatinine, AST and ALT) was completed in this study. Each parameter has been divided into two categories based on its vitamin D3 status. Vitamin D3 samples that fall into the first group G1 are those that have an adequate amount, whereas samples that fall into the second group G2 have insufficient levels of the vitamin. The findings were as follows: Vitamin D3 levels significantly decreased in deficient patients when compared to sufficient subjects (P 0.05). Females and rural participants both had greater rates of vitamin D3 insufficiency than males and urban subjects. While there was no discernible variation in ALT level between G1 and G2 samples, there was a substantial rise in ALT enzyme among G2 samples when compared to G. There were no discernible variations in the levels of urea, uric acid, or creatinine between the two groups.

References

Ardesia M, Ferlazzo G, Fries W. Vitamin D and inflammatory bowel disease. BioMed Research International, 2015, 2015.

Joshi SR. Vitamin D paradox in plenty sunshine in rural India-an emerging threat. JAPI, 2008, 56.

Du C, Yang S, Zhao X, Dong H. Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis. Oncotarget. 2017;25;8(17):29474.

Jäpelt RB, Jakobsen J. Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. Frontiers in plant science. 2013;13(4):136.

Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & Biology. 2014;2021(3):319-29.

Mathieu C, Gysemans C. Vitamin D and diabetes. Av Diabetol. 2006;22(3):18793.

Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The American journal of clinical nutrition. 2004;80(6):1678S-88S.

Calvo MS, Whiting SJ, Barton CN. Vitamin D intake: a global perspective of current status. The Journal of Nutrition. 2005;135(2):310-6.

Ali Ali OA. Vitamin D levels in Adult patients with Hemophilia. Unversity of Gaziantep, 2018.

Hatem AK, Lateef HF. The state of Vitamin D in Iraqi Patients with Parkinson Disease. Al-Kindy College Medical Journal. 2017;13(1):137-41.

Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? The Journal of steroid biochemistry and molecular biology. 2014;144:138-45.

Holick MF. Vitamin D Status: Measurement, Interpretation and Clinical Application. Ann Epidemoil. 2009;19(2):73-78.

Reitman S, Frankel S, Amer J. Clin. Path. 1957;28:56.

Young DS. Effects of Drugs on Clinical Laboratory Tests. Third Edition. 1990;3:612.

Krieg M, et al. J. Clin. Chem. Clin. Biochem. 1986;24:863.

TIETZ NW. Text book of clinical chemistry, 3rd Ed. C.A. Burtis, E.R. Ashwood, W.B. Saunders, 1999, 1241-1245.

Issa AM, Ibraheem SA. Alterations of vitamin” D” level in sera of Iraqi population. Journal of Kerbala University. 2007;5(1):58-64.

Darwish LAAI. Vitamin D status in healthy femal individuals. ALKufa Unversity Journal of Biology, 2018, 10(1).

Sulaiman AH, Abukanna AM, Alenezy AA, Balla AA. Prevalence of Vitamin D deficiency among University Female Students in Northern Border Region of Kingdom of Saudi Arabia (KSA). Annals of Medical and Health Sciences Research, 2017.

Al-Elq AH. The status of vitamin D in medical students in the pre-clerkship years in a Saudi Medical School. J Fam Community Med. 2012;19:100-104.

Sharif Elham, Rizk Nasser, Jasim Ameena, Mohamed Asma. The Prevalence of Vitamin D3 Deficiency Among College Females at Qatar University (Pilot study). First regional nutrition conference. Qatar University.

Qatatsheh A, Tayyem R, Al-Shami I, Al-Holy MA, Al-Rethaia AS. Vitamin D deficiency among Jordanian university students and employees. Nutrition & Food Science. 2015;45(1):68-82.

Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Archives of Pediatrics & Adolescent Medicine. 2004 Jan;158(6):531-7.

Sharawat I, Sitaraman S, Dawman L. Prevalence of Vitamin D Deficiency among Healthy School Children in Jaipur District, Rajasthan, India. International Journal of Pediatrics. 2015 Jan;3(4.2):801.

Holick HL. Biochemistry and physiology-Aspect of Nutrition. 4th Ed. Mosbey, 2004.

Jhon GR. competitive protein binding redio assay for 25(OH) D3. Journal Clinical Endocr. Metab. 1971;33:9925.

Al-Elq AH. The status of Vitamin D in medical students in the preclerkship years of a Saudi medical school. Journal of Family & Community medicine. 2012;19(2):100.

Faghih S, Abdolahzadeh M, Mohammadi M, Hasanzadeh J. Prevalence of vitamin d deficiency and its related factors among university students in Shiraz, Iran. International Journal of Preventive Medicine. 2014;5(6):796.

Kaddam IM, Al-Shaikh AM, Abaalkhail BA, Asseri KS, Al-Saleh YM, Al-Qarni AA, Al-Shuaibi AM, Tamimi WG, Mukhtar AM. Prevalence of vitamin D deficiency and its associated factors in three regions of Saudi Arabia: A cross-sectional study. Saudi medical journal. 2017;38(4):381.

Shin Y, Kim K, Lee C, Shin H, Kang M, Lee H, et al. High prevalence of vitamin D insufficiency or deficiency in young adolescents in Korea. Journal of Pediatrics. 2012;171:1475-1480. doi: 10.1007/s004310-1746-012-European.

Sharawat I, Sitaraman S, Dawman L. Prevalence of Vitamin D Deficiency among Healthy School Children in Jaipur District, Rajasthan, India. International Journal of Pediatrics. 2015 Jan;3(4.2):801.

Ning Z, Song S, Miao L, Zhang P, Wang X, Liu J, et al. High prevalence of vitamin D deficiency in urban health checkup population. Clinical Nutrition. 2016;31;35(4):859-63.

Suryanarayana P, Arlappa N, Sai Santhosh V, Balakrishna N, Lakshmi Rajkumar P, Prasad U, et al. Prevalence of vitamin D deficiency and its associated factors among the urban elderly population in Hyderabad metropolitan city, South India. Annals of Human Biology. 2018;45(2):133-9.

Fang F, Wei H, Wang K, Tan L, Zhang W, Ding L, et al. High prevalence of vitamin D deficiency and influencing factors among urban and rural residents in Tianjin, China. Archives of Osteoporosis. 2018;13(1):64.

Butta, Yasmeen F, Alavi n. Comparison of Vitamin D levels between urban and rural college students.

Ardawi MS, Qari MH, Rouzi AA, Maimani AA, Raddadi RM. Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre-and postmenopausal women. Osteoporosis International. 2011;22(2):463-75.

Holick MF. Vitamin D deficiency. New England Journal of Medicine. 2007;357(3):266-81.

Chesney RW. Vitamin D and The Magic Mountain: the anti-infectious role of the vitamin. The Journal of pediatrics. 2010;156(5):698-703.

Abbas RS, Abdulridha MK, Shafek MA, Najim HD. Correlation between Endogenous Vitamin D Status and Body Mass Index in Asthmatic Patients Receiving Adjuvant Vitamin D3 Supplement. Karbala Journal of Pharmaceutical Sciences. 2017;13:106-21.

Boonpiyathad T, Pradubpongsa P, Sangasapaviriya A. Vitamin D supplements improve urticaria symptoms and quality of life in chronic spontaneous urticarial patients: a prospective case-control study. Dermato-Endocrinology. 2016;8(1):e983685.

Youssef DA, Miller CW, El-Abbassi AM, Cutchins DC, Cutchins C, Grant WB, et al. Antimicrobial implications of vitamin D. Dermato-Endocrinology. 2011;3(4):220-9.

Al-Dhubaibi MS. Association between Vitamin D deficiency and psoriasis: An exploratory study. International Journal of Health Sciences. 2018 Jan;12(1):33.

Skaaby T, Husemoen LL, Borglykke A, Jørgensen T, Thuesen BH, Pisinger C, et al. Vitamin D status, liver enzymes, and incident liver disease and mortality: a general population study. Endocrine. 2014;47(1):213-20.

Kasapoglu B, Turkay C, Yalcin KS, Carlioglu A, Sozen M, Koktener A. Low vitamin Dlevels are associated wıth increased risk for fatty liver disease among non-obese adults. Clinical Medicine. 2013;13(6):576.

Özkan EA, Göçmen AY. Association Between Thyroid Function Tests, Liver Enzymes and Vitamin D in Healthy Children. 2016;9(1):7-12.

Kwo PY, Cohen SM, Lim JK. ACG Clinical guideline: evaluation of abnormal liver chemistries. The American Journal of Gastroenterology. 2017;112(1):18.

Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB. Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests. Clinical Chemistry. 2000;46(12):2027-49.

Malham M, Jørgensen SP, Ott P, Agnholt J, Vilstrup H, Borre M, et al. Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology. World Journal of Gastroenterology (WJG). 2011;17(7):922.

Barchetta I, Carotti S, Labbadia G, Gentilucci UV, Muda AO, Angelico F, et al. Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus. Hepatology. 2012;56(6):2180-7.

Barchetta I, Carotti S, Labbadia G, Gentilucci UV, Muda AO, Angelico F, et al. Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus. Hepatology. 2012;56(6):2180-7.

Ding N, Ruth TY, Subramaniam N, Sherman MH, Wilson C, Rao R, et al. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell. 2013;153(3):601-13.

Putz-Bankuti C, Pilz S, Stojakovic T, Scharnagl H, Pieber TR, Trauner M, et al. Association of 25-hydroxyvitamin d levels with liver dysfunction and mortality in chronic liver disease. Liver Int. 2012;32:845-851. [CrossRef] [PubMed].

2017 National Kidney Foundation, Inc., 30 East 33rd Street, New York, NY 10016, 19010-622-800. We subscribe to the HONcode principles of the Health on the Net Foundation.

Bentli R, Taskapan H, Toktaş H, Ulutas O, Ozkahraman A, Comert M. Significant Independent predictors of vitamin D deficiency in inpatients and outpatients of a nephrology unit. International Journal of Endocrinology, 2013, 2013.

Xiao X, Wang Y, Hou Y, Han F, Ren J, Hu Z. Vitamin D deficiency and related risk factors in patients with diabetic nephropathy. Journal of International Medical Research. 2016;44(3):673-84.

Christiansen C, Ro̸dbro P, Christensen M, Hartnack B, Transbol IB. Deterioration of renal function during treatment of chronic renal failure with 1, 25-dihydroxycholecalciferol. The Lancet. 1978;312(8092):700-3.

Perez A, Raab R, Chen TC, Turner A, Hollck M. Safety and efficacy of oral calcitriol (1, 25‐dihydroxyvitamin D3) for the treatment of psoriasis. British Journal of Dermatology. 1996 Jun;134(6):1070-8.

Agarwal R, Hynson JE, Hecht TJ, Light RP, Sinha AD. Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate. Kidney International. 2011;80(10):1073-9.

Thakkinstian A, Anothaisintawee T, Chailurkit L, Ratanachaiwong W, Yamwong S, Sritara P, et al. Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis. Scientific reports. 2015;5:14528.

Nath SD, Voruganti VS, Arar NH, Thameem F, Lopez-Alvarenga JC, Bauer R, et al. Genome scan for determinants of serum uric acid variability. Journal of the American Society of Nephrology. 2007;18(12):3156-63.

John P. Forman, Instructor in Medicine, Brigham and Women’s Hospital, Brigham and Women’s Hospita, 2017.

Downloads

Published

2023-09-04

How to Cite

Hussein, I. A. (2023). Study association between vitamin d3 with liver function and kidney in student. Journal of Advanced Education and Sciences, 3(5), 08–14. Retrieved from https://dzarc.com/education/article/view/384

Issue

Section

Articles