Need of disintegrants and super-disintegrants in tablet formulations: a brief report

Authors

  • Ramchandra Verma Research Scholar, Department of Pharmaceutics, Pacific College of Pharmacy, PAHER University, Udaipur, Rajasthan, India
  • Ayush Garg Associate Professor, Department of Pharmaceutics, Pacific College of Pharmacy, PAHER University, Udaipur, Rajasthan, India
  • Jayesh Dwivedi Professor, Department of Pharmaceutics, Pacific College of Pharmacy, PAHER University, Udaipur, Rajasthan, India

Keywords:

disintegrants, superdisintegrants, SSG, fast dissolving, orally disintegrating

Abstract

The disintegrants are the agents which are added to a tablet or some capsule formulations to aid moisture penetration and dispersion of the matrix of dosage form in dissolution media. An oral solid dosage form must disperse into the primary solid particles from which it was prepared. Super-disintegrants are normally used at a low concentration, 1-10% by weight relative to total weight of dosage unit. Generally used superdisintegrants are croscarmellose sodium, crospovidone, sodium starch glycolate, etc. The selection of suitable formulation excipients and manufacturing technology is necessary for obtaining the optimized design features of orally disintegrating dosage forms.

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Published

2022-08-29

How to Cite

Verma, R., Garg, A., & Dwivedi, J. (2022). Need of disintegrants and super-disintegrants in tablet formulations: a brief report. Journal of Advanced Education and Sciences, 2(3), 33–36. Retrieved from https://dzarc.com/education/article/view/143

Issue

Vol. 2 No. 3 (2022)

Section

Articles

License

Copyright (c) 2022 Ramchandra Verma, Ayush Garg, Jayesh Dwivedi

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This work is licensed under a Creative Commons Attribution 4.0 International License.